Lin Xie Selected Research

Central Nervous System Diseases (CNS Diseases)

1/2022	Imaging of Transmembrane AMPA Receptor Regulatory Proteins by Positron Emission Tomography.
1/2019	Development of 2-(2-(3-(4-([18F]Fluoromethoxy- d2)phenyl)-7-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)-4-isopropoxyisoindoline-1,3-dione for Positron-Emission-Tomography Imaging of Phosphodiesterase 10A in the Brain.
11/2017	In Vivo Monitoring for Regional Changes of Metabotropic Glutamate Receptor Subtype 1 (mGluR1) in Pilocarpine-Induced Epileptic Rat Brain by Small-Animal PET.
1/2016	Dynamic Changes in Striatal mGluR1 But Not mGluR5 during Pathological Progression of Parkinson's Disease in Human Alpha-Synuclein A53T Transgenic Rats: A Multi-PET Imaging Study.
1/2014	PET brain kinetics studies of (11)C-ITMM and (11)C-ITDM,radioprobes for metabotropic glutamate receptor type 1, in a nonhuman primate.
7/2013	Synthesis and evaluation of [11C]MMPIP as a potential radioligand for imaging of metabotropic glutamate 7 receptor in the brain.
10/2012	In vivo measurement of the affinity and density of metabotropic glutamate receptor subtype 1 in rat brain using 18F-FITM in small-animal PET.
8/2011	Peripheral anti-inflammatory effects explain the ginsenosides paradox between poor brain distribution and anti-depression efficacy.

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Lin Xie Research Topics

Disease

53	Neoplasms (Cancer) 06/2022 - 06/2006
23	Inflammation (Inflammations) 01/2022 - 03/2011
21	Stroke (Strokes) 03/2022 - 11/2002
20	Brain Ischemia (Cerebral Ischemia) 03/2022 - 11/2002
20	Type 2 Diabetes Mellitus (MODY) 12/2020 - 04/2008
19	Infarction (Infarctions) 03/2022 - 11/2002
19	Ischemia 01/2022 - 03/2002
16	Neoplasm Metastasis (Metastasis) 06/2022 - 01/2013
12	Hypoxia (Hypoxemia) 08/2013 - 03/2002
11	Glaucoma 01/2022 - 11/2013
10	Breast Neoplasms (Breast Cancer) 06/2022 - 06/2006
10	Melanoma (Melanoma, Malignant) 01/2021 - 09/2011
10	Alzheimer Disease (Alzheimer's Disease) 01/2020 - 01/2004
9	Intervertebral Disc Degeneration 01/2022 - 05/2014
9	Neuroinflammatory Diseases 04/2018 - 11/2006
9	Hypoglycemia (Reactive Hypoglycemia) 01/2017 - 11/2011
8	Wounds and Injuries (Trauma) 01/2022 - 11/2002
8	Central Nervous System Diseases (CNS Diseases) 01/2022 - 08/2011
8	Pain (Aches) 08/2021 - 12/2009
8	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 01/2013 - 06/2003
7	Fibrosis (Cirrhosis) 01/2022 - 11/2015
7	Hepatocellular Carcinoma (Hepatoma) 01/2021 - 01/2019
7	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2019 - 01/2004
6	Schizophrenia (Dementia Praecox) 01/2020 - 05/2015
5	Osteosarcoma (Osteogenic Sarcoma) 04/2022 - 12/2016
5	Ischemic Stroke 03/2022 - 11/2002
5	Osteoporosis 01/2022 - 04/2014
5	Reperfusion Injury 01/2022 - 07/2012
5	Carcinogenesis 06/2021 - 01/2013
5	Nervous System Diseases (Neurological Disorders) 02/2021 - 01/2003
5	Disease Progression 09/2020 - 12/2010
5	Lung Neoplasms (Lung Cancer) 11/2019 - 01/2015
5	Diabetes Mellitus 05/2014 - 12/2006
4	Hemophilia A (Haemophilia) 03/2022 - 01/2018
4	Myocardial Ischemia (Ischemic Heart Diseases) 01/2022 - 11/2006
4	Autoimmune Diseases (Autoimmune Disease) 01/2022 - 01/2009
4	Atherosclerosis 10/2021 - 12/2015
4	Spinal Cord Injuries (Spinal Cord Injury) 10/2021 - 04/2013
4	Glioma (Gliomas) 06/2021 - 11/2017
4	Adenocarcinoma of Lung 01/2021 - 01/2013
4	Cicatrix (Scar) 01/2020 - 11/2013
4	Diabetic Retinopathy (Retinopathy, Diabetic) 01/2020 - 09/2008
4	Hemorrhage 01/2018 - 06/2013
3	Cataract (Cataracts) 01/2022 - 11/2017
3	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2022 - 01/2019
3	Pneumonia (Pneumonitis) 09/2021 - 01/2012
3	Glioblastoma (Glioblastoma Multiforme) 06/2021 - 01/2007
3	Hypertension (High Blood Pressure) 01/2021 - 01/2011

Drug/Important Bio-Agent (IBA)

42	Proteins (Proteins, Gene)FDA Link 01/2022 - 09/2003
15	Insulin (Novolin)FDA Link 12/2020 - 01/2011
14	Biomarkers (Surrogate Marker)IBA 01/2022 - 11/2012
11	Insulin Glargine (Lantus)FDA Link 07/2019 - 01/2011
10	LigandsIBA 01/2019 - 12/2009
9	MicroRNAs (MicroRNA)IBA 12/2021 - 01/2013
9	NeuroglobinIBA 08/2013 - 03/2003
8	Pharmaceutical PreparationsIBA 02/2022 - 04/2010
7	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2022 - 06/2003
7	Messenger RNA (mRNA)IBA 01/2021 - 10/2003
7	Glutamic Acid (Glutamate)FDA Link 01/2020 - 07/2013
7	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 02/2019 - 12/2006
7	Bromodeoxyuridine (BrdU)IBA 01/2012 - 07/2002
6	CytokinesIBA 03/2022 - 03/2012
6	Therapeutic UsesIBA 03/2022 - 04/2018
6	Biological ProductsIBA 01/2021 - 01/2007
6	metabotropic glutamate receptor type 1IBA 01/2020 - 10/2012
6	EnzymesIBA 02/2019 - 03/2011
6	Neuroprotective AgentsIBA 01/2018 - 04/2004
5	Fatty Acids (Saturated Fatty Acids)IBA 01/2022 - 03/2011
5	Long Noncoding RNAIBA 12/2021 - 10/2018
5	RNA (Ribonucleic Acid)IBA 01/2021 - 01/2013
5	Hypoglycemic Agents (Hypoglycemics)IBA 07/2019 - 01/2013
5	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 03/2007 - 07/2002
4	Peptides (Polypeptides)IBA 04/2022 - 04/2019
4	LipidsIBA 01/2021 - 01/2016
4	Glucose (Dextrose)FDA LinkGeneric 12/2020 - 09/2008
4	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2018 - 03/2003
4	Opioid Analgesics (Opioids)IBA 08/2015 - 06/2014
4	Phosphotransferases (Kinase)IBA 08/2014 - 10/2003
4	LipopolysaccharidesIBA 01/2013 - 08/2011
3	Methionine (L-Methionine)FDA Link 08/2022 - 11/2012
3	Valoctocogene RoxaparvovecIBA 03/2022 - 06/2020
3	Neurotransmitter Agents (Neurotransmitter)IBA 01/2022 - 12/2019
3	Myeloid Differentiation Factor 88IBA 01/2022 - 01/2016
3	Retinaldehyde (Retinal)IBA 01/2022 - 10/2018
3	Temozolomide (Temodar)FDA LinkGeneric 06/2021 - 02/2018
3	Small Interfering RNA (siRNA)IBA 01/2021 - 04/2012

Therapy/Procedure

40	Therapeutics 12/2021 - 01/2004
7	Transplantation 02/2022 - 03/2005
7	Drug Therapy (Chemotherapy) 08/2020 - 11/2003
6	Filtering Surgery 01/2022 - 11/2013
6	Vertebroplasty 12/2020 - 12/2009
6	Diskectomy (Discectomy) 09/2020 - 06/2015
5	Trabeculectomy (Trabeculoplasty) 01/2022 - 10/2015
5	Injections 10/2021 - 01/2014
4	Radiotherapy 01/2022 - 11/2003
4	Immunotherapy 01/2022 - 09/2011
4	Length of Stay 11/2019 - 10/2015
4	Aftercare (After-Treatment) 01/2019 - 12/2009
4	Breast Implants (Breast Implant) 10/2012 - 06/2006
3	Immunomodulation 06/2022 - 03/2013